Serotonin transporter Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,ELISA | Bioss

2026-05-01~2026-06-30,AB2605
Serotonin transporter Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,ELISA | Bioss
货号:bs-1893R
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概述

产品编号
bs-1893R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Serotonin transporter Rabbit pAb
中文名称
5-羟色胺转运蛋白抗体
英文别名
5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT; SC6A4_HUMAN; SLC6A4; 5HT transporter (5HTT); Solute carrier family 6 member 4; SC6A4_MOUSE; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; 5-hydroxytryptamine (serotonin) transporter; obsessive-compulsive disorder 1; solute carrier family 6 (neurotransmitter transporter), member 4; serotonin transporter 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human 5-HTT: 401-500/630 <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
70 kDa
检测分子量
70 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
SERT是一种钠依赖单胺转运蛋白,由630个氨基酸组成,相对分子质量为:70KDa
背景资料
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008].
5-羟色胺转运蛋白抗体-bs-1893R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouse, RatHuman1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
ELISAHuman, Mouse, Rat1:5000-10000

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
SLC6A4
蛋白名
Sodium-dependent serotonin transporter
亚基
Monomer or homooligomer. Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.
亚细胞定位
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
组织特异性
Expressed in platelets (at protein level).
翻译后修饰
Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms (By similarity).
Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation (By similarity). Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.
相似性
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
功能
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

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