PRKACA Rabbit pAb (一抗) | Bioss
货号：bs-7479R
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概述
产品编号
bs-7479R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
PRKACA Rabbit pAb
中文名称
蛋白激酶A催化亚基抗体
英文别名
CAFD1; PKACA; PPNAD4; CAFD2; PKA C-beta; PKACB; PKCD; CbPKA; Cs-PKA; PKCA1; KAPCA_HUMAN; PRKACA; PKA C-alpha; 2.7.11.11; KAPCB_HUMAN; PRKACB; KAPCA_MOUSE; KAPB_MOUSE; KAPCA_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human cAMP Protein Kinase Catalytic subunit: 1-100/351
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
40 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Types of disease > Cancer
Neuroscience > Neurotransmission > Intracellular Signaling > Kinases
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKA
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKC
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
激酶和磷酸酶（Kinases and Phosphatases）
蛋白激酶 A (protein kinase A，PKA) 又称依赖于cAMP的蛋白激酶A (cyclic-AMP dependent protein kinase A)，是一种结构最简单、生化特性最清楚的蛋白激酶。
蛋白激酶A属于多功能丝氨酸和苏氨酸激酶,可使蛋白磷酸化，也可自身磷酸化。在调节细胞存活中起重要作用。
蛋白激酶 A (protein kinase A，PKA) 又称依赖于cAMP的蛋白激酶A (cyclic-AMP dependent protein kinase A)，是一种结构最简单、生化特性最清楚的蛋白激酶。
蛋白激酶A属于多功能丝氨酸和苏氨酸激酶,可使蛋白磷酸化，也可自身磷酸化。在调节细胞存活中起重要作用。
背景资料
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PKA beta (catalytic subunit) is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse | Rat, Rabbit, Pig, Sheep, Cow, Dog | 1:100-500 |
| IHC-F | Human, Mouse | Rat, Rabbit, Pig, Sheep, Cow, Dog | 1:100-500 |
| IF | Human, Mouse | Rat, Rabbit, Pig, Sheep, Cow, Dog | 1:100-500 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Cow, Dog)
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靶标
基因名
PRKACA
蛋白名
cAMP-dependent protein kinase catalytic subunit alpha
亚基
A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity).
亚细胞定位
oplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
组织特异性
Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
翻译后修饰
Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
疾病
A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
相似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
功能
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
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