FADD Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bs-0511R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-0511R
产品类型
农牧业/家禽抗体
英文名称
FADD Rabbit pAb
中文名称
Fas死亡结构域相关蛋白抗体
英文别名
Mort1/FADD; FADD_MOUSE; Fadd; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Mort1; GIG3; IMD90; FADD_HUMAN; Growth-inhibiting gene 3 protein;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human FADD: 1-80/205
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
23 kDa
检测分子量
23 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
FADD属于TNFR家族，有死亡区的Fas相关蛋白。
背景资料
Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Rat | Mouse, Rabbit, Pig | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Pig | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig | 1:100-500 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Rabbit, Pig)
相关产品
暂无相关产品
靶标
基因名
FADD
蛋白名
FAS-associated death domain protein
亚基
Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8.
组织特异性
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
疾病
The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
相似性
Contains 1 death domain.
Contains 1 DED (death effector) domain.
Contains 1 DED (death effector) domain.
功能
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-0511R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bs-0511R 被引用于7文献中