ATG14 Rabbit pAb (一抗) | Bioss
货号：bs-7462R
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概述
产品编号
bs-7462R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
ATG14 Rabbit pAb
中文名称
自噬相关蛋白14抗体
英文别名
ATG14L; BARKOR; KIAA0831; 4832427M01; D14Ertd114e; D14Ertd436e; RGD1304610; BAKOR_HUMAN; ATG14; Autophagy-related protein 14-like protein (Atg14L); BAKOR_MOUSE; BAKOR_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ATG14: 41-140/492
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
55 kDa
检测分子量
68 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Pig, Cow, Dog | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Pig, Cow, Dog | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Pig, Cow, Dog | 1:100-500 |
| IF | Human | Mouse, Rat, Pig, Cow, Dog | 1:100-500 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Pig, Cow, Dog)
相关产品
暂无相关产品
靶标
基因名
ATG14
蛋白名
Beclin 1-associated autophagy-related key regulator
亚基
Component of the autophagy-specific PI3-kinase complex I composed of ATG14, BECN1, PIK3C3 and PIK3R4, but not UVRAG, nor KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with PIK3CB (By similarity). Interacts with BECN1P1/BECN2.
亚细胞定位
Cytoplasm. Endoplasmic reticulum. Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes.
相似性
Belongs to the Barkor family.
功能
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.
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