5-脂氧合酶重组兔单抗

bsm-61061R

重组兔单抗、mIHC精品抗体

5 Lipoxygenase Recombinant Rabbit mAb

5-脂氧合酶重组兔单抗

5-LO; 5-LOX; 5LPG; LOG5; 5LO; 5LX; F730011J02; LOX5A; LOX5_HUMAN; ALOX5; Arachidonate 5-lipoxygenase (5-LO | 5-lipoxygenase); 1.13.11.-; LOX5_MOUSE; LOX5_RAT;

Rabbit

A synthesized peptide derived from human 5 Lipoxygenase: 120-155

IgG

Liquid

affinity purified by Protein A

Recombinant

18A12

78

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

5-脂氧合酶蛋白(5-LOX; 5-lipoxygenase; Arachidonate 5-lipoxygenase; 5-LO; ALOX5 )是花生四烯酸代谢途径中的一种关键酶,在恶性肿瘤的发生、发展过程中起了重要作用.抑制5-脂氧合酶及其产物的表达有可能预防和逆转恶性肿瘤的发生。

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.