O位N-乙酰葡萄糖胺OGT重组兔单抗

bsm-61036R

重组兔单抗

OGT Recombinant Rabbit mAb

O位N-乙酰葡萄糖胺OGT重组兔单抗

HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1; XLID106; 1110038P24Rik; 4831420N21Rik; Ogtl; OGT1_HUMAN; OGT; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit (OGT); 2.4.1.255; OGT1_MOUSE; OGT1_PIG; OGT1_RAT;

Rabbit

A synthesized peptide derived from human OGT: 1000-1046

IgG

Liquid

affinity purified by Protein A

Recombinant

7A5

117

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5 and HCFC1. Promotes proteolytic maturation of HCFC1. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. O-GlcNAc transferase has been purified from rat liver. It exists as a heterotrimeric complex with two subunits of the same molecular mass and one shorter subunit. Both polypeptides are related; the short subunit band is either a proteolytic product of the polypeptide or the product of an alternative translation start site. O-GlcNAc transferase is expressed as multiple transcripts that are present in different amounts in various human tissues, with the highest levels of expression in pancreas. Immunofluorescence of human cells expressing rat O-GlcNAc transferase indicated that it is present in both the nucleus and cytosol. HeLa cells expressing O-GlcNAc transferase do not survive well during prolonged incubations, suggesting that this protein may be toxic to the cells.