5-羟色胺受体2C重组兔单抗

bsm-61025R

重组兔单抗

5HT2C Receptor Recombinant Rabbit mAb

5-羟色胺受体2C重组兔单抗

5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C; 5HT-1C; 5HT2C_HUMAN; HTR2C; 5-HT-2C; 5-hydroxytryptamine receptor 1C (5-HT-1C | 5-HT1C); Serotonin receptor 2C; 5HT2C_RAT; 5ht1c;

Rabbit

A synthesized peptide derived from human 5 HT2C: 406-458

IgG

Liquid

affinity purified by Protein A

Recombinant

7D11

52

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq, Jul 2008].