酪氨酸激酶C-SRC重组兔单抗

bsm-61019R

重组兔单抗

CSK Recombinant Rabbit mAb

酪氨酸激酶C-SRC重组兔单抗

CSK_BOVIN; CSK; C-Src kinase; 2.7.10.2; CSK_HUMAN; Protein-tyrosine kinase CYL; CSK_MOUSE; Protein-tyrosine kinase MPK-2; p50CSK; CSK_RAT;

Rabbit

A synthesized peptide derived from human CSK: 70-100/450

IgG

Liquid

affinity purified by Protein A

Recombinant

7H2

51

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.