APPL1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-61064R

重组兔单抗

APPL1 Recombinant Rabbit mAb

衔接因子蛋白含pH域蛋白1重组兔单抗

APPL; DIP13alpha; MODY14; 2900057D21Rik; 7330406P05Rik; DIP13; RGD1309388; DP13A_HUMAN; APPL1; Dip13-alpha; Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; DIP13A; KIAA1428; DP13A_MOUSE; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha

Rabbit

A synthesized peptide derived from human Dip13 alpha: 400-450/709

Liquid

affinity purified by Protein A

Recombinant

6F1

80 kDa

80 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链基元1抗体.
APPL1可调节脂联素和胰岛素信号，是细胞膜与细胞核之间重要的信息传递蛋白,同时也是细胞增殖所必需的蛋白，它有调节脂联素在脂肪酸氧化和葡萄糖吸收中的作用，APPL1通过激酶通道来调节脂联素的胰岛素敏感效应。

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

APPL1

DCC-interacting protein 13-alpha

Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Interacts with OCRL and INPP5B.

Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

High levels in heart, ovary, pancreas and skeletal muscle.

Phosphorylated upon DNA damage, probably by ATM or ATR.
Phosophorylation at Ser-410 by PKA severely impairs binding to OCRL.

Contains 1 PH domain.
Contains 1 PID domain.

Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.