The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Rabbit
1:1000-2000
IHC-P
Human
Rabbit
1:50-200
IHC-F
Human
Rabbit
1:50-200
IF
Human
Rabbit
1:50-200
IP
Human, Rabbit
1:20-100
交叉反应
交叉反应: Human (predicted: Rabbit)
相关产品
暂无相关产品
靶标
基因名
FSHB
蛋白名
Follitropin subunit beta
亚基
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
亚细胞定位
Secreted.
疾病
Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.
相似性
Belongs to the glycoprotein hormones subunit beta family.
功能
Stimulates development of follicle and spermatogenesis in the reproductive organs.