尿路上皮特异蛋白3重组兔单抗

bsm-61004R

重组兔单抗、mIHC精品抗体

UPK3A Recombinant Rabbit mAb

尿路上皮特异蛋白3重组兔单抗

UP3A; UPIII; UPIIIA; UPK3; UPK3A_HUMAN; UPK3A; Uroplakin III (UPIII); Q32N05_HUMAN;

Rabbit

A synthesized peptide derived from human Uroplakin 3a: 220-287/287

IgG

Liquid

affinity purified by Protein A

Recombinant

19A15

29 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.