Myosin Light Chain 2 Recombinant Rabbit mAb (一抗) | Bioss

bsm-61001R

重组兔单抗

Myosin Light Chain 2 Recombinant Rabbit mAb

心脏肌球蛋白轻链2重组兔单抗

MLC-2s/v; CMH10; MFM12; MLC-2; MLC-2v; MLC2; Gm32672; Mlc2v; Mylpc; MLRV_BOVIN; MYL2; Myosin light chain 2, slow skeletal/ventricular muscle isoform (MLC-2s/v); MLRV_HUMAN; Cardiac myosin light chain 2; Ventricular myosin light chain 2; MLRV_MOUSE; MLRV_RAT; myosin light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow; myosin, light chain 2, regulatory, cardiac, slow; cardiac ventricular myosin light chain 2

Rabbit

A synthesized peptide derived from human Myosin light chain 2: 100-166/166

IgG

Liquid

affinity purified by Protein A

Recombinant

12D4

20 kDa

19 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MYL2

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Cytoplasm, myofibril, sarcomere, A band

Expressed in fetal and adult skeletal muscle.

N-terminus is methylated by METTL11A/NTM1.

Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.

Contains 3 EF-hand domains.

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.