EGFR Knockout Hela Cell Line (Pool) (KO细胞系) | Bioss
货号：K004-5-3P
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概述
产品编号
K004-5-3P
产品类型
KO/KD细胞系
英文名称
EGFR Knockout Hela Cell Line (Pool)
中文名称
EGFR基因敲除Hela细胞（Pool）
英文别名
EGF R; Epidermal growth factor receptor; erbb 1; Erbb; Erbb1; HER1; Receptor tyrosine protein kinase ErbB 1; EGFR_HUMAN.
SWISS
Gene ID
gRNA种属
Human
细胞名称
Hela
培养体系
90％DMEM + 10％FBS + 1％P/S
冻存液体系
90％FBS + 10％DMSO
敲除区域
E17
鉴定方法
PCR + Sanger Sequencing
突变描述
Knockout achieved by using CRISPR/Cas9, Deletion of the selection cassette in exon 17.
细胞数目
1-5×10⁶
产品组成
1 vial knockout cell line and 1 vial parental cell line.
运输条件
Dry Ice
保存条件
Stored in liquid nitrogen for a long time.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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靶标
基因名
EGFR
蛋白名
Epidermal growth factor receptor