磷酸化干扰素诱导的双链RNA活化蛋白激酶重组兔单抗

bsm-52189R

磷酸化抗体、重组兔单抗

phospho-PKR (Thr446) Recombinant Rabbit mAb

磷酸化干扰素诱导的双链RNA活化蛋白激酶重组兔单抗

EIF2AK2 | PKR (phospho-T446); p-PKR; phospho-PKR; p-EIF2AK2; DYT33; EIF2AK1; LEUDEN; PKR; PPP1R83; PRKR; E2AK2_HUMAN; EIF2AK2; Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2); Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated (PKR | Protein kinase R); Tyrosine-protein kinase EIF2AK2; p68 kinase; 2.7.11.1;

Rabbit

A synthesized peptide derived from human eIF2A K2 around the phosphorylation site of T446: KR-pT-RS

IgG

Liquid

affinity purified by Protein A

Recombinant

10A1

62 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

蛋白激酶R/双链RNA依赖蛋白激酶（PKR）是一种干扰素诱导的、双链RNA激活的丝氨酸/苏氨酸激酶, PKR在信号转导、细胞生长、分化和凋亡的控制中起重要作用.也有人认为：PKR是一个重要的凋亡效应物,是许多不同刺激物诱导凋亡的一个转导物。

PKR is an interferon-inducible serine/threonine specific protein kinase. It is widely expressed in eukaryotic organisms and activated by double stranded RNA. Activation of PKR by dsRNAs leads to autophosphorylation at multiple sites. Phosphorylation of Thr446 and Thr451 in the PKR activation loop is required in vivo and in vitro for high level kinase activity. PKR phosphorylates its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor 2 (EIF2 alpha), leading to the inhibition of protein synthesis. PKR is also involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, and also activates IKK and NFKB, thereby suppressing apoptosis. Recently, it has been reported that PKR also phosphorylates human p53 on serine 392. PKR might play a role in ER stress-induced apoptosis and in Alzheimer's disease. Alzheimer cases show prominent PKR activation in association with neuritic plaques and pyramidal neurons in the hippocampus and neocortex.