ATP依赖解旋酶RENT1重组兔单抗
Rrmab®兔单抗
货号：bsm-54402R
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概述
产品编号
bsm-54402R
产品类型
重组兔单抗
英文名称
hUPF1 Recombinant Rabbit mAb
中文名称
ATP依赖解旋酶RENT1重组兔单抗
英文别名
HUPF1; NORF1; RENT1; UTF; pNORF1; smg-2;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Regulator of nonsense transcripts 1: 1-53
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8B15
理论分子量
124 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| Flow-Cyt | Human | Mouse | 1ug/Test |
| ICC/IF | Human | Mouse | 1:100-500 |
| IP | Human, Mouse | 1:10-50 |
交叉反应
交叉反应: Human (predicted: Mouse)
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靶标
基因名
UPF1
蛋白名
Regulator of nonsense transcripts 1
亚基
Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1. Interacts with UPF2, UPF3A and UPF3B. Interacts with EST1A and SLBP. Interacts (when hyperphosphorylated) with PNRC2. Interacts with EIF2C1, EIF2C2 and GSPT2.
亚细胞定位
Cytoplasm. Cytoplasm, P-body. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
组织特异性
Ubiquitous.
翻译后修饰
Phosphorylated by SMG1; required for formation of mRNA surveillance complexes. Phosphorylated upon DNA damage, probably by ATM or ATR.
相似性
Belongs to the DNA2/NAM7 helicase family.
Contains 1 C2H2-type zinc finger.
Contains 1 C2H2-type zinc finger.
功能
Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability.
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