hUPF1 Recombinant Rabbit mAb (一抗) | Bioss

bsm-54402R

重组兔单抗

hUPF1 Recombinant Rabbit mAb

ATP依赖解旋酶RENT1重组兔单抗

HUPF1; NORF1; RENT1; UTF; pNORF1; smg-2; UPF1 RNA helicase and ATPase; regulator of nonsense transcripts 1; UPF1 regulator of nonsense transcripts homolog (yeast); UPF1, RNA helicase and ATPase; UP Frameshift 1; smg-2 homolog, nonsense mediated mRNA decay factor (C. elegans)

Rabbit

A synthesized peptide derived from human Regulator of nonsense transcripts 1: 1-53

IgG

Liquid

affinity purified by Protein A

Recombinant

8B15

124 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.

UPF1

Regulator of nonsense transcripts 1

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1. Interacts with UPF2, UPF3A and UPF3B. Interacts with EST1A and SLBP. Interacts (when hyperphosphorylated) with PNRC2. Interacts with EIF2C1, EIF2C2 and GSPT2.

Cytoplasm. Cytoplasm, P-body. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.

Ubiquitous.

Phosphorylated by SMG1; required for formation of mRNA surveillance complexes. Phosphorylated upon DNA damage, probably by ATM or ATR.

Belongs to the DNA2/NAM7 helicase family.
Contains 1 C2H2-type zinc finger.

Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability.