谷氨酰胺转胺酶2重组兔单抗

bsm-55541R

重组兔单抗、mIHC精品抗体

Transglutaminase 2 Recombinant Rabbit mAb

谷氨酰胺转胺酶2重组兔单抗

G(h); TG(C); TGC; hTG2; tTG; G[a]h; TG2; TGase2; tTGas; TGM2_HUMAN; TGM2; Erythrocyte transglutaminase; Heart G alpha(h) (hhG alpha(h)); Isopeptidase TGM2; Protein G alpha(h) (G(h)); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; Tissue transglutaminase (tTG | tTgase); Transglutaminase C (TG(C) | TGC | TGase C); Transglutaminase H (TGase H); Transglutaminase II (TGase II); Transglutaminase-2 (TG2 | TGase-2 | hTG2); 2.3.2.13; TGM2_MOUSE; Tissue transglutaminase (tTG); Transglutaminase-2 (TG2 | TGase-2 | TGase2);

Rabbit

A synthesized peptide derived from human TGM2: 560-615/687

IgG

Liquid

Affinity Purification

Recombinant

17E10

78

78

PBS with 100 μg/ml BSA,0.15% ProClin300 and 50% glycerol.

Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

谷氨酰胺转移酶2（TGM2）是一种钙离子依赖酶，通过催化赖氨酸与谷氨酰胺残基之间形成化学键，可以将胞质和细胞外基质蛋白进行交联。这种双功能酶也有内在GTP酶活性，研究表明，转酰氨基酶活性的调节有可能通过G蛋白偶联受体信号转导通路进行调节。在交联肽中，TGM2可以帮助调节细胞骨架结构、细胞迁移、凋亡和细胞基质粘附。另外，该酶在创伤愈合与免疫应答中起重要作用。TGM2显示有体外激酶活性，胰岛素样生长因子结合蛋白3（IGFBP-3）为其潜在底物。这种广泛表达的蛋白定位于胞质与胞核之中，但是从细胞表面与细胞外基质中也有分离，由于其与许多不同的底物有相互作用，以及在损伤应答中的作用，TGM2与许多人疾病病理有关。TGM2长期被认为是腹腔疾病的自身抗原，其表达或活性变化可能与阿尔茨海默病、亨廷顿病、动脉硬化、糖尿病以及与多种癌症有关联。

Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components.