Aconitase 2 Rabbit pAb (一抗) | Bioss
货号：bs-2390R
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概述
产品编号
bs-2390R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Aconitase 2 Rabbit pAb
中文名称
铁调节蛋白2抗体
英文别名
ACONM; HEL-S-284; ICRD; OCA8; OPA9; ACON_HUMAN; ACO2; Aconitase; Citrate hydro-lyase; 4.2.1.3;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Aconitase 2: 651-750/780
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
86 kDa
检测分子量
82 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
Signal Transduction > Metabolism > Energy Metabolism
Signal Transduction > Metabolism > Mitochondrial
Tags & Cell Markers > Subcellular Markers > Organelles > Mitochondria
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat, Rabbit, Pig, Cow, Dog, Horse)
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靶标
基因名
ACO2
蛋白名
Aconitate hydratase, mitochondrial
亚基
Monomer.
亚细胞定位
Mitochondrion.
疾病
Infantile cerebellar-retinal degeneration (ICRD) [MIM:614559]: A severe autosomal recessive neurodegenerative disorder characterized by onset between ages 2 and 6 months of truncal hypotonia, athetosis, seizures, and ophthalmologic abnormalities, particularly optic atrophy and retinal degeneration. Affected individuals show profound psychomotor retardation, with only some achieving rolling, sitting, or recognition of family. Brain MRI shows progressive cerebral and cerebellar degeneration. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the aconitase/IPM isomerase family.
功能
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
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