多配体蛋白聚糖1（CD138）重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28，RR26012026-01-04~2026-02-28，TR
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多配体蛋白聚糖1（CD138）重组兔单抗
货号：bsm-60902R
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概述

产品编号
bsm-60902R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
CD138 Recombinant Rabbit mAb
中文名称
多配体蛋白聚糖1（CD138）重组兔单抗
英文别名
CD138; SDC; SYND1; syndecan; SDC1_HUMAN; SDC1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CD138
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5D12
理论分子量
34 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域

Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins

Cancer > Invasion/microenvironment > ECM > Extracellular matrix

Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

Metabolism > Types of disease > Cancer

Neuroscience > Cell Adhesion Proteins > ECM Proteins

Neuroscience > Cell Adhesion Proteins > Membrane Proteins

Neuroscience > Cell Type Marker > Neuron marker > Synapse marker

Neuroscience > Neurology process > Neurogenesis

Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Glucosaminoglycans

Signal Transduction > Cytoskeleton / ECM > HSPGs

Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage

SWISS
P18827
Gene ID
6382
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 6382 Human

SwissProt : P18827 Human

产品介绍
Syndecan1(CD138)属于Syndecans基因家族，该家族是一类细胞表面跨膜蛋白多糖 ,是膜表面粘附受体 ,参与细胞-细胞外基质之间的粘附。
CD138表达于上皮细胞、胚胎间质细胞、血管平滑肌细胞、内皮细胞和神经细胞基底膜。Syndecan-1与恶性肿瘤的发生发展、浸润及转移有关，着色于胞浆和胞膜.
背景资料
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
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产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PHuman1:100-500
IHC-FHuman1:100-500
IFHuman1:100-500

交叉反应

交叉反应: Human

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靶标

基因名
SDC1
蛋白名
Syndecan-1
亚基
Interacts with CDCP1.
亚细胞定位
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
翻译后修饰
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
相似性
Belongs to the syndecan proteoglycan family.
功能
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

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