TGF alpha Rabbit pAb (一抗) - WB | Bioss
货号：bs-0066R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-0066R
英文名称
TGF alpha Rabbit pAb
中文名称
转移生长因子α抗体
英文别名
TFGA; wa-1; wa1; RATTGFAA; TGFAA; TGFA_HUMAN; TGFA; TGFA_MOUSE; TGFA_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from mouse TGF-alpha
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
17 kDa
检测分子量
15 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
生长因子和激素
TGFα是一个强有力的只有丝分裂多肽,主要由恶性肿瘤产生。
TGFα是一个强有力的只有丝分裂多肽,主要由恶性肿瘤产生。
背景资料
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
TGFA
蛋白名
Protransforming growth factor alpha
亚基
Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.
亚细胞定位
Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.
组织特异性
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
相似性
Contains 1 EGF-like domain.
功能
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro).
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-0066R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bs-0066R 被引用于1文献中