The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:1000-5000
IHC-P
Human
1:100-500
IHC-F
Human
1:100-500
IF
Human
1:100-500
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
TNFRSF8
蛋白名
Tumor necrosis factor receptor superfamily member 8
亚基
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
亚细胞定位
Isoform Long: Cell membrane; Single-pass type I membrane protein. Isoform Short: Cytoplasm.
组织特异性
Detected in thymus and in activated splenocytes.
翻译后修饰
Phosphorylated on serine and tyrosine residues.
相似性
Contains 6 TNFR-Cys repeats
功能
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.