磷酸化一氧化氮合成酶3（内皮型）重组兔单抗
Rrmab®兔单抗
货号：bsm-54795R
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概述
产品编号
bsm-54795R
产品类型
磷酸化抗体、重组兔单抗
英文名称
phospho-eNOS (Ser1177) Recombinant Rabbit mAb
中文名称
磷酸化一氧化氮合成酶3（内皮型）重组兔单抗
英文别名
NOS3 | eNOS (phospho-S1177); p-eNOS; phospho-eNOS; p-NOS3; ECNOS; eNOS; 2310065A03Rik; Nos-3; NOS3_BOVIN; NOS3; Constitutive NOS (cNOS); EC-NOS; NOS type III (NOSIII); Nitric oxide synthase, endothelial (Endothelial NOS | eNOS); 1.14.13.39; NOS3_HUMAN; NOS3_MOUSE; NOS3_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human eNOS around the phosphorylation site of Ser1177:
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12H2
理论分子量
133 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cardiovascular > Blood > Platelets
Cardiovascular > Vasculature > Vasodilation > Nitric oxide associated
Cell Biology > Other Antibodies > Oxidative Stress
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
合成与降解（Synthesis and Degradation)
催化生物体内一氧化氮（NO）生成的酶。分神经型一氧化氮合成的酶（nNOS or NOS-1）、诱导型一氧化氮合成的酶（iNOS or NOS-2）、内皮型一氧化氮合成的酶（eNOS or NOS-3）。此抗体识别分子量为135kDa的内皮型一氧化氮合成的酶。
催化生物体内一氧化氮（NO）生成的酶。分神经型一氧化氮合成的酶（nNOS or NOS-1）、诱导型一氧化氮合成的酶（iNOS or NOS-2）、内皮型一氧化氮合成的酶（eNOS or NOS-3）。此抗体识别分子量为135kDa的内皮型一氧化氮合成的酶。
背景资料
Nitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
NOS3
蛋白名
Nitric oxide synthase, endothelial
亚基
Homodimer. Interacts with NOSIP and NOSTRIN.
亚细胞定位
Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
组织特异性
Platelets, placenta, liver and kidney.
翻译后修饰
Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity. Phosphorylation of Ser-114 by CDK5 reduces activity.
相似性
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
功能
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
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