谷氨酰胺酶重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
谷氨酰胺酶重组兔单抗
货号:bsm-60888R
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概述

产品编号
bsm-60888R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Glutaminase Recombinant Rabbit mAb
中文名称
谷氨酰胺酶重组兔单抗
英文别名
AAD20; CASGID; DEE71; EIEE71; GAC; GAM; GDPAG; GLS1; KGA; 6330442B14; B230365M23Rik; Glut; RATGLUT; GLSK_HUMAN; GLS; K-glutaminase; L-glutamine amidohydrolase; 3.5.1.2; KIAA0838; GLSK_MOUSE; GLSK_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GLS: 50-101/669
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
15H3
理论分子量
73 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHumanMouse, Rat1:200-500
IHC-FHumanMouse, Rat1:200-500
IFHumanMouse, Rat1:200-500
Flow-CytHumanMouse, Rat1ug/Test
ICC/IFHumanMouse, Rat1:100-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
GLS
蛋白名
Glutaminase kidney isoform, mitochondrial
亚基
Heterotetramer. Interacts with ATCAY; the interaction is direct and may control GLS localization, negatively regulating its activity.
亚细胞定位
Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion.
组织特异性
Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle.
相似性
Belongs to the glutaminase family.
Contains 2 ANK repeats.
功能
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

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