This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:1000-2000
IHC-P
Human, Mouse, Rat
1:200-800
IHC-F
Human, Mouse, Rat
1:200-800
IF
Human, Mouse, Rat
1:200-800
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
SLC1A3
蛋白名
Excitatory amino acid transporter 1
亚细胞定位
Membrane; Multi-pass membrane protein
组织特异性
Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
翻译后修饰
Glycosylated.
疾病
Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
相似性
Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.
功能
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.