细胞间粘附分子-1（CD54）重组兔单抗
KO/KD Validated
Rrmab®兔单抗
货号：bsm-52466R
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概述
产品编号
bsm-52466R
产品类型
重组兔单抗、KO/KD Validated、mIHC精品抗体
英文名称
ICAM1 Recombinant Rabbit mAb
中文名称
细胞间粘附分子-1（CD54）重组兔单抗
英文别名
BB2; CD54; P3.58; Icam-1; Ly-47; MALA-2; ICAM; ICAM1_HUMAN; ICAM1; Major group rhinovirus receptor; ICAM1_MOUSE; MyD10; ICAM1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ICAM 1: 20-60
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1G2
理论分子量
56 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Angiogenesis > Endothelial Cell Markers
Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell adhesion molecules
Immunology > Adaptive Immunity > Regulatory T Cells
Immunology > Cell Type Markers > CD > Adhesion
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD54（ICAM-1）是分子量为60-110KD的膜型糖蛋白，表达于单核和内皮细胞。许多细胞如B或T淋巴细胞、胸腺细胞、纤维母细胞和上皮细胞都可诱导表达CD54，在调节免疫和炎症反应中CD54有重要作用。
背景资料
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:1000-5000 | |
| IHC-P | Human | 1:200-1000 | |
| IHC-F | Human | 1:200-1000 | |
| IF | Human | 1:200-1000 |
交叉反应
交叉反应: Human
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靶标
基因名
ICAM1
蛋白名
Intercellular adhesion molecule 1
亚基
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
亚细胞定位
Membrane; Single-pass type I membrane protein.
翻译后修饰
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
相似性
Belongs to the immunoglobulin superfamily. ICAM family.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.
功能
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
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