NOX2重组兔单抗

bsm-52603R

重组兔单抗

NOX2 Recombinant Rabbit mAb

NOX2重组兔单抗

NOX2; AMCBX2; CGD; CGDX; GP91-1; GP91-PHOX; GP91PHOX; IMD34; p91-PHOX; CGD91-phox; Cyd; CY24B_BOVIN; CYBB; Cytochrome b(558) subunit beta (Cytochrome b558 subunit beta); Cytochrome b-245 heavy chain; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; 1.6.3.-; CY24B_HUMAN; Superoxide-generating NADPH oxidase heavy chain subunit; CY24B_MOUSE;

Rabbit

A synthesized peptide derived from human NOX2: 142-204/570

IgG

Liquid

affinity purified by Protein A

Recombinant

9B12

65 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NOX2也是一个很重要的产生氧自由基的酶。主要存在于甲状腺,前列腺，唾液腺和直肠粘膜中。

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.