Dishevelled 2 Rabbit pAb (一抗) | Bioss
货号：bs-10400R
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概述
产品编号
bs-10400R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Dishevelled 2 Rabbit pAb
中文名称
蓬乱蛋白2抗体
英文别名
Dvl-2; DVL2_HUMAN; DVL2; Dishevelled-2; DSH homolog 2; DVL2_MOUSE; dishevelled segment polarity protein 2; dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2 (Drosophila)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human shevelled 2: 421-520/736
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
79 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Pig, Sheep, Cow, Dog, Horse)
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靶标
基因名
DVL2
蛋白名
Segment polarity protein dishevelled homolog DVL-2
亚基
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex. Interacts with DACT1.
亚细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta.
翻译后修饰
Phosphorylated by CSNK1D.
相似性
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
功能
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.
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