Melan A Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52337R

重组兔单抗

Melan A Recombinant Rabbit mAb

黑色素瘤相关抗原/黑色素-A重组兔单抗

MART-1; MART1; MAR1_HUMAN; MLANA; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; melan-A

Rabbit

A synthesized peptide derived from human MART1: 2-33

IgG

Liquid

affinity purified by Protein A

Recombinant

6E11

13 kDa

15 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号中间体（Signaling Intermediates）
MelanA/MART-1是分化肿瘤抗原类别中具有代表性的成员，它表达于正常的黑素细胞和大多数原发及转移的黑色素瘤中，故称：黑色素瘤相关抗原。

Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.

MLANA

Melanoma antigen recognized by T-cells 1

Interacts with PMEL. Interacts with GPR143.

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Expression is restricted to melanoma and melanocyte cell lines and retina.

Acylated.

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.