Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Rat
1:500-2000
IHC-P
Mouse, Rat
1:100-500
IHC-F
Mouse, Rat
1:100-500
IF
Mouse, Rat
1:100-500
交叉反应
交叉反应: Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
ARG1
蛋白名
Arginase-1
亚基
Homotrimer.
亚细胞定位
Cytoplasm.
疾病
Defects in ARG1 are the cause of argininemia (ARGIN) ; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.