TXNIP Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

Cancer > Cancer Metabolism > Cellular metabolic process

Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates

Cancer > Oncoproteins/suppressors > Tumor suppressors

Cell Biology > Other Antibodies > Oxidative Stress

Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors

Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors

Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism

Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism

Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

Signal Transduction > Metabolism > Energy Metabolism

SwissProt : Q9H3M7 Human

Entrez Gene : 10628 Human

    硫氧还蛋白结合蛋白-2 (TRX-binding protein-2，TBP-2)又称:维生素D3上调蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或称硫氧还蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。
TBP-2与硫氧还蛋白(thioredoxin，TRX)的活性部位结合，抑制其活性，除了参与多种氧化应激反应，还具有多种生物学功能。
有学者认为：TBP-2与肿瘤密切相关，有些肿瘤组织中，TBP-2表达降低或缺失。TBP-2表达增高时，细胞周期停滞，肿瘤细胞繁殖受到抑制。目前已成为肿瘤研究的重要靶点。

TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).