硫氧还蛋白结合蛋白2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28，RR26012026-01-04~2026-02-28，TR
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硫氧还蛋白结合蛋白2重组兔单抗
货号：bsm-54127R
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概述

产品编号
bsm-54127R
产品类型
重组兔单抗
英文名称
TXNIP Recombinant Rabbit mAb
中文名称
硫氧还蛋白结合蛋白2重组兔单抗
英文别名
TXNIP_HUMAN; TXNIP; Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1; VDUP1; ARRDC6; EST01027; HHCPA78; THIF;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human TXNIP: 30-95
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8A11
理论分子量
44 kDa
浓度
1mg/ml
储存液
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.
研究领域

Cancer > Cancer Metabolism > Cellular metabolic process

Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates

Cancer > Oncoproteins/suppressors > Tumor suppressors

Cell Biology > Other Antibodies > Oxidative Stress

Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors

Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors

Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism

Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism

Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

Signal Transduction > Metabolism > Energy Metabolism

SWISS
Q9H3M7
Gene ID
10628
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

SwissProt : Q9H3M7 Human

Entrez Gene : 10628 Human

产品介绍
    硫氧还蛋白结合蛋白-2 (TRX-binding protein-2，TBP-2)又称:维生素D3上调蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或称硫氧还蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。
TBP-2与硫氧还蛋白(thioredoxin，TRX)的活性部位结合，抑制其活性，除了参与多种氧化应激反应，还具有多种生物学功能。
有学者认为：TBP-2与肿瘤密切相关，有些肿瘤组织中，TBP-2表达降低或缺失。TBP-2表达增高时，细胞周期停滞，肿瘤细胞繁殖受到抑制。目前已成为肿瘤研究的重要靶点。
背景资料
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHumanMouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
ICC/IFMouseHuman, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
TXNIP
蛋白名
Thioredoxin-interacting protein
亚基
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.
亚细胞定位
Cytoplasm
翻译后修饰
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
相似性
Belongs to the arrestin family.
功能
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

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