Myc重组兔单抗
Rrmab®兔单抗
货号：bsm-56001R
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概述
产品编号
bsm-56001R
产品类型
重组兔单抗
英文名称
C-Myc Recombinant Rabbit mAb
中文名称
Myc重组兔单抗
英文别名
MRTL; MYCC; bHLHe39; c-Myc; Myc2; Niard; Nird; RNCMYC; mMyc; MYC_HUMAN; MYC; Class E basic helix-loop-helix protein 39 (bHLHe39); Proto-oncogene c-Myc; Transcription factor p64; MYC_MOUSE; MYC_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human c Myc: 1-50
亚型
IgG1
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
18H19
理论分子量
51 kDa
检测分子量
62 kDa
浓度
1mg/ml
储存液
0.1M Phosphate Buffered Saline, pH7.4.
研究领域
Cancer > Cell cycle > Cell differentiation
Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors
Cancer > Tumor biomarkers > Oncoproteins
Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH / Leucine Zipper
Epigenetics and Nuclear Signaling > Transcription > Transcription Factors
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
分子式：C51H86N12O21
分子量：1203.3
纯度：＞99%
序列：H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH (EQKLISEEDL)
外购/性状：白色粉末
来源：合成 溶解性：溶于水、1%醋酸或缓冲液TBS (50mM Tris-HCl, pH7.4, 150mM NaCl)
用途：c-Myc Tag 标签多肽是一种常用于通过竞争性结合标签抗体，从而在免疫沉淀时洗脱与标签抗体结合的标签融合表达蛋白的多肽。可用于免疫磁珠在免疫沉淀时标签融合表达蛋白的洗脱。
分子量：1203.3
纯度：＞99%
序列：H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH (EQKLISEEDL)
外购/性状：白色粉末
来源：合成 溶解性：溶于水、1%醋酸或缓冲液TBS (50mM Tris-HCl, pH7.4, 150mM NaCl)
用途：c-Myc Tag 标签多肽是一种常用于通过竞争性结合标签抗体，从而在免疫沉淀时洗脱与标签抗体结合的标签融合表达蛋白的多肽。可用于免疫磁珠在免疫沉淀时标签融合表达蛋白的洗脱。
背景资料
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:2000-10000 | |
| Flow-Cyt | Human | 1μg/Test | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
MYC
蛋白名
Myc proto-oncogene protein
亚基
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66.
亚细胞定位
Nucleus, nucleoplasm.
组织特异性
Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature.
翻译后修饰
Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex.
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex.
疾病
Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
相似性
Contains 1 basic helix-loop-helix (bHLH) domain.
功能
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
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