E cadherin Rabbit pAb (一抗) | Bioss

bs-1016R

宠物抗体、农牧业/家禽抗体

E cadherin Rabbit pAb

上皮钙粘附分子抗体

Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO; E-cad; L-CAM; Um; Cadherin-1; Uvomorulin; CADH1_BOVIN; CDH1; Epithelial cadherin (E-cadherin); CADH1_HUMAN; CAM 120/80; CADH1_MOUSE; CADH1_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human E-cadherin: 801-882/882 <Cytoplasmic>

IgG

Liquid

affinity purified by Protein A

Polyclonal

90/97 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞粘附蛋白（Call Adhesion Protein）
E-chaherin是研究较多的同质粘附分子。E-cadherin的表达与恶性肿瘤的分化程度、侵袭力、转移负相关与预后正相关，E-cadherin的低表达和不稳定表达可促进转移的发生。近年来已成为肿瘤细胞侵袭和转移研究的热点之一。

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]