骨桥蛋白/分泌型磷蛋白1重组兔单抗

bsm-43600R

重组兔单抗

Osteopontin Recombinant Rabbit mAb

骨桥蛋白/分泌型磷蛋白1重组兔单抗

BNSP; BSPI; ETA-1; OPN; 2AR; Apl-1; Bsp; Eta; OP; Opnl; Ric; Spp-1; OSP; OSTP_HUMAN; SPP1; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1 (SPP-1); Urinary stone protein; Uropontin; OSTP_MOUSE; Calcium oxalate crystal growth inhibitor protein; Early T-lymphocyte activation 1 protein; Minopontin; OSTP_RAT; 2b7;

Rabbit

Recombinant human Osteopontin protein: 17-314/314

IgG

Size : 25ul/50ul/100ul/200ul
Liquid

Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.

affinity purified by Protein A

Recombinant

1D1

35 kDa

1mg/ml

Size : 25ul/50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

骨桥蛋白（osteopontin）又称为早期Ｔ淋巴细胞活化因子Ｉ或分泌型磷蛋白Ｉ,是一种重要的多功能细胞外基质蛋白,在骨组织细胞、巨噬细胞、平滑肌细胞、内皮细胞及上皮细胞等多种细胞上表达,在介导细胞的趋化、聚集、黏附、增殖和迁移,以及骨组织的矿化与重建、免疫调节、信号转导和对感染性疾病的免疫能力等方面有着重要的作用。
ＯＰＮ在细胞免疫中的功能：1.ＯＰＮ对炎性细胞的作用：炎症是炎性细胞(单核巨噬细胞、淋巴细胞、中性粒细胞等)在炎症部位的聚集,适度的炎症对机体有益,如抗感染及促进组织细胞功能恢复等;但过度的炎症能引起组织损伤等有害作用。ＯＰＮ在炎症中具有促炎及抗炎双重作用；2.ＯＰＮ对淋巴细胞的作用：早期的报道称ＯＰＮ是Ｔ淋巴细胞抑制因子,它可抑制Ｔ淋巴细胞而促进Ｂ淋巴细胞及肥大细胞的分化、增殖
骨桥蛋白(osteopontin，OPN)是一种含精氨酸—甘氨酸—天冬氨酸(Arg-Gly-Asp，RGD)的分泌型糖基化磷蛋白，已归类于细胞外基质(extracellular matrix，ECM)蛋白。 OPN既是细胞因子，又是细胞黏附分子。
OPN最初是从骨组织分离的，而后在上皮细胞、胃肠道的分泌物、肾、甲状腺、睾丸以及一些肿瘤细胞里都陆续的发现了OPN的表达。在生殖方面，OPN在分泌期子宫内膜上皮细胞、侵袭的滋养细胞、蜕膜细胞中表达。

Osteopontin is the principal phosphorylated glycoprotein of bone and is expressed in a limited number of other tissues including dentine. Osteopontin is produced by osteoblasts under stimulation by calcitriol and binds tightly to hydroxyapatite. It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. Osteopontin is overexpressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma.