Toll样受体7重组兔单抗
Rrmab®兔单抗
货号：bsm-41320R
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概述
产品编号
bsm-41320R
产品类型
重组兔单抗
英文名称
TLR7 Recombinant Rabbit mAb
中文名称
Toll样受体7重组兔单抗
英文别名
IMD74; SLEB17; TLR7-like; TLR7_HUMAN; TLR7; TLR7_MOUSE;
抗体来源
Rabbit
免疫原
Recombinant human TLR7 protein: 24-348/1049
亚型
IgG
性状
Size : 25ul/50ul/100ul/200ul
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8H7
理论分子量
121 kDa
浓度
1mg/ml
储存液
Size : 25ul/50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| Flow-Cyt | Human | Mouse, Rat | 1ug/Test |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
TLR7
蛋白名
Toll-like receptor 7
亚基
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.
亚细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
组织特异性
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
相似性
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
功能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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