连接粘附分子1重组兔单抗
Rrmab®兔单抗
货号：bsm-52561R
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概述
产品编号
bsm-52561R
产品类型
重组兔单抗
英文名称
F11R/JAM-A/CD321 Recombinant Rabbit mAb
中文名称
连接粘附分子1重组兔单抗
英文别名
CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1; 9130004G24; ESTM33; JAM-1; JAM-A; Jcam1; Ly106; JAM1_HUMAN; F11R; Junctional adhesion molecule 1 (JAM-1); Platelet F11 receptor; Platelet adhesion molecule 1 (PAM-1); JAM1_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human JAM A: 1-62
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7E1F
理论分子量
30 kDa
浓度
1mg/ml
储存液
1xTBS (pH7.4), 1% BSA, 40% Glycerol and 0.02% Proclin300.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Junctional Adhesion Molecule 1 (JAM1) seems to play a role in epithelial tight junction formation. It appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. JAM1 plays a role in regulating monocyte transmigration involved in integrity of the epithelial barrier. JAM1 is also involved in platelet activation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
F11R
蛋白名
Junctional adhesion molecule A
亚基
Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).
亚细胞定位
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
翻译后修饰
N-glycosylated.
相似性
Belongs to the immunoglobulin superfamily.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
功能
Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
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