Name: 异染色质蛋白1-γ/HP-1γ单克隆抗体（CBX3 | HP1 gamma Mouse mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-33376M
Availability: InStock

概述

产品编号

bsm-33376M

英文名称

CBX3 | HP1 gamma Mouse mAb

中文名称

异染色质蛋白1-γ/HP-1γ单克隆抗体

英文别名

HECH; HP1-GAMMA; HP1Hs-gamma; HP1gamma; HP1g; M32; CBX3_HUMAN; CBX3; Heterochromatin protein 1 homolog gamma (HP1 gamma); Modifier 2 protein; CBX3_MOUSE; chromobox 3; chromobox homolog 3 (Drosophila HP1 gamma); chromobox homolog 3; HP1 gamma homolog (Drosophila)

抗体来源

Mouse

免疫原

Recombinant human HP1 gamma Protein: full length

性状

Size : 50ul/100ul/200ul
Liquid

Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.

纯化方法

affinity purified by Protein G

克隆类型

Monoclonal

克隆号

6F4

理论分子量

21 kDa

检测分子量

21 kDa

浓度

1mg/ml

储存液

Size : 50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS (pH7.4).

研究领域

Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > Methyl Lysine

Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > Methylated DNA

SWISS

Q13185

Gene ID

11335

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 11335 Human

Entrez Gene : 12417 Mouse

Entrez Gene : 297093 Rat

Omim : 604477 Human

SwissProt : Q13185 Human

SwissProt : P23198 Mouse

Unigene : 381189 Human

Unigene : 280968 Mouse

Unigene : 458234 Mouse

Unigene : 485141 Mouse

背景资料

HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

基因名

CBX3

蛋白名

Chromobox protein homolog 3

亚基

Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.

亚细胞定位

Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).

翻译后修饰

Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.

相似性

Contains 2 chromo domains.

功能

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.