自噬微管相关蛋白轻链3重组兔单抗

bsm-60842R

重组兔单抗

LC3B Recombinant Rabbit mAb

自噬微管相关蛋白轻链3重组兔单抗

ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a; 1010001C15Rik; Atg8; MAP1A/MAP1B; Map1lc3; Mpl3; zbs559; MLP3B_HUMAN; MAP1LC3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; Microtubule-associated proteins 1A/1B light chain 3B (MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B); MAP1ALC3; MLP3B_MOUSE; MLP3B_RAT;

Rabbit

A synthesized peptide derived from human LC3B: 1-110

IgG/Kappa

Liquid

affinity purified by Protein A

Recombinant

7D10

15 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.