Caveolin-1 Recombinant Rabbit mAb (一抗) | Bioss

bsm-60809R

重组兔单抗

Caveolin-1 Recombinant Rabbit mAb

细胞质膜微囊蛋白-1重组兔单克隆抗体

BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21; Cav; Cav-1; CAV1_CANLF; CAV1; Vesicular integral-membrane protein VIP21; CAV1_HUMAN; CAV1_MOUSE; CAV1_RAT; caveolin 1; caveolin 1, caveolae protein, 22kD; caveolin 1, caveolae protein, 22kDa

Rabbit

KLH conjugated synthetic peptide derived from human Caveolin-1

IgG

Liquid

affinity purified by Protein A

Recombinant

19E17

20 kDa

1mg/ml

PBS, Glycerol, BSA.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号传导（Signaling Intermediates）
Caveolin-1（小凹蛋白）是细胞生长相关信号途径及肿瘤发生发展过程中重要的抑制因子，Caveolae是细胞膜内的特殊膜结构，参与包括细胞的分子运输、细胞粘附和信号转导在内的多种细胞活动。Caveolin-1是Caveolae中重要的结构蛋白，抑制细胞生长，与多种人类肿瘤发生发展相关的信号分子相互作用。Caveolin在信号转导的整合中起支架蛋白的作用。Caveolin构成了一个蛋白家族，他们是细胞质膜中发夹样结构域的主要结构成分。Caveolin在信号转导的整合中起支架蛋白的作用。至今已经鉴定了3种Caveolin （Caveolin-1、2 和3），它们具有不同的组织分布。Caveolin-1涉及乳腺上皮细胞增生的发病机制。该抗体可识别α和β型Caveolin-1。

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq].