微小染色体维持缺陷蛋白7重组兔单克隆抗体

bsm-60801R

重组兔单抗、mIHC精品抗体

MCM7 Recombinant Rabbit mAb

微小染色体维持缺陷蛋白7重组兔单克隆抗体

CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104; Mcmd7; mCDC47; MCM7_HUMAN; MCM7; CDC47 homolog; 3.6.4.12; MCM7_MOUSE;

Rabbit

KLH conjugated synthetic peptide derived from human MCM7

IgG

Liquid

affinity purified by Protein A

Recombinant

20E7

79 kDa

1mg/ml

PBS, Glycerol, BSA.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Mcm7是微小染色体维持蛋白家族成员之一,与其他的Mcm蛋白形成异多聚体,调节DNA的复制.在启动DNA复制、合成中起到关键作用,在增殖细胞或组织表达较高,可以作为肿瘤生物标志物。

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].