PSMA1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

Rrmab?兔单抗
2026-03-02~2026-04-30,KXJ2603
PSMA1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号:bsm-60572R
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概述

产品编号
bsm-60572R
产品类型
重组兔单抗
英文名称
PSMA1 Recombinant Rabbit mAb
中文名称
蛋白酶体PSMα1重组兔单抗
英文别名
HC2; HEL-S-275; NU; PROS30; C2; Pros-30; alpha-type; PSA1_CHICK; PSMA1; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; PSA1_HUMAN; 30 kDa prosomal protein (PROS-30); Proteasome nu chain; Proteasome subunit alpha-6 (alpha-6); PSC2; PSA1_MOUSE; PSA1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PSMA1: 210-263/263
亚型
IgG/Kappa
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
C12B5
检测分子量
30 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Ubiquitin-dependent proteolysis mediates selective destruction of various cell cycle regulators, transcription factors and tumor suppressors. In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome form, facilitating proteolysis. 20S Proteasome ?, also designated macropain subunit C2 or PROS-30, is a prosomal protein involved in a non-lysosomal ATP/ubiquitin-dependent proteolytic pathway. The entire proteasome is composed of at least 15 non-identical subunits which form a highly-ordered ring-shaped structure.
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
Flow-CytHumanMouse, Rat1:50-100
ICC/IFHumanMouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
PSMA1
蛋白名
Proteasome subunit alpha type-1
亚基
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with bacterial.
亚细胞定位
Cytoplasm. Nucleus.
组织特异性
Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.
相似性
Belongs to the peptidase T1A family.
功能
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.

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