PSMA1 | HC2/PROS-30 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-60572R

重组兔单抗

PSMA1 | HC2/PROS-30 Recombinant Rabbit mAb

蛋白酶体PSMα1重组兔单抗

HC2; HEL-S-275; NU; PROS30; C2; Pros-30; alpha-type; PSA1_CHICK; PSMA1; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; PSA1_HUMAN; 30 kDa prosomal protein (PROS-30); Proteasome nu chain; Proteasome subunit alpha-6 (alpha-6); PSC2; PSA1_MOUSE; PSA1_RAT; proteasome 20S subunit alpha 1; proteasome (prosome, macropain) subunit, alpha type, 1; proteasome subunit alpha 1; proteasome subunit α6

Rabbit

A synthesized peptide derived from human PSMA1: 210-263/263

IgG/Kappa

Liquid

affinity purified by Protein A

Recombinant

C12B5

30 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ubiquitin-dependent proteolysis mediates selective destruction of various cell cycle regulators, transcription factors and tumor suppressors. In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome form, facilitating proteolysis. 20S Proteasome ?, also designated macropain subunit C2 or PROS-30, is a prosomal protein involved in a non-lysosomal ATP/ubiquitin-dependent proteolytic pathway. The entire proteasome is composed of at least 15 non-identical subunits which form a highly-ordered ring-shaped structure.

PSMA1

Proteasome subunit alpha type-1

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with bacterial.

Cytoplasm. Nucleus.

Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.

Belongs to the peptidase T1A family.

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.