核糖核酸酶L抑制蛋白重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
核糖核酸酶L抑制蛋白重组兔单抗
货号:bsm-60444R
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概述

产品编号
bsm-60444R
产品类型
重组兔单抗
英文名称
ABCE1 Recombinant Rabbit mAb
中文名称
核糖核酸酶L抑制蛋白重组兔单抗
英文别名
ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I; RNS41; ABCE1_HUMAN; ABCE1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor (RNS4I); 3.6.5.-; ABCE1_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ABCE1: 574-599
亚型
IgG/Kappa
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
A12F4
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. It is alternatively referred to as the RNase L inhibitor as it functions to block the activity of ribonuclease L(referenced from entrez gene).
核糖核酸酶L抑制蛋白重组兔单抗核糖核酸酶L抑制蛋白重组兔单抗核糖核酸酶L抑制蛋白重组兔单抗核糖核酸酶L抑制蛋白重组兔单抗核糖核酸酶L抑制蛋白重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:50-200
IHC-FHuman, Mouse, Rat1:50-200
IFHuman, Mouse, Rat1:50-200
Flow-CytHumanMouse, Rat1:50-100
ICC/IFHuman, Mouse, Rat1:50-200
IPHuman, Mouse, Rat1:20-50

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
ABCE1
蛋白名
ATP-binding cassette sub-family E member 1
亚基
Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.
亚细胞定位
Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.
相似性
Belongs to the ABC transporter superfamily. ABCE family.
Contains 2 4Fe-4S ferredoxin-type domains.
Contains 2 ABC transporter domains.
功能
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

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