ABCE1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,IP | Bioss
Rrmab?兔单抗
货号：bsm-60444R
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概述
产品编号
bsm-60444R
产品类型
重组兔单抗
英文名称
ABCE1 Recombinant Rabbit mAb
中文名称
核糖核酸酶L抑制蛋白重组兔单抗
英文别名
ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I; RNS41; ABCE1_HUMAN; ABCE1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor (RNS4I); 3.6.5.-; ABCE1_MOUSE; ATP binding cassette subfamily E member 1; ATP-binding cassette, sub-family E (OABP), member 1; RNase L inhibitor 1
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ABCE1: 574-599
亚型
IgG/Kappa
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
A12F4
检测分子量
67 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. It is alternatively referred to as the RNase L inhibitor as it functions to block the activity of ribonuclease L(referenced from entrez gene).
基因名
ABCE1
蛋白名
ATP-binding cassette sub-family E member 1
亚基
Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.
亚细胞定位
Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.
相似性
Belongs to the ABC transporter superfamily. ABCE family.
Contains 2 4Fe-4S ferredoxin-type domains.
Contains 2 ABC transporter domains.
Contains 2 4Fe-4S ferredoxin-type domains.
Contains 2 ABC transporter domains.
功能
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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