ACTH Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-60798R

重组兔单抗

ACTH Recombinant Rabbit mAb

促肾上腺皮质激素重组兔单克隆抗体

ACTH; CLIP; LPH; MSH; NPP; OBAIRH; POC; BE; Beta-LPH; Gamma-LPH; Pomc-1; Pomc1; alpha-MSH; alphaMSH; beta-MSH; gamma-MSH; Pomc2; COLI_BOVIN; POMC; Corticotropin-lipotropin; COLI_HUMAN; COLI_MOUSE; COLI_RAT; proopiomelanocortin; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte stimulating hormone; beta-endorphin; adrenocorticotropic hormone; opiomelanocortin prepropeptide; corticotropin

Rabbit

A synthesized peptide derived from human POMC: 110-180/267

IgG

Liquid

affinity purified by Protein A

Recombinant

A1H9

4.5/29 kDa

29 kDa

1mg/ml

PBS, Glycerol, BSA.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

POMC

Pro-opiomelanocortin

Belongs to the POMC family.

Secreted.

ACTH and MSH are produced by the pituitary gland.

Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.

Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.

Belongs to the POMC family.

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.