CD74重组兔单克隆抗体

bsm-60795R

重组兔单抗、病理级抗体、mIHC精品抗体

CD74 Recombinant Rabbit mAb

CD74重组兔单克隆抗体

CLIP; DHLAG; HLADG; II; Ia-GAMMA; p33; HG2A_HUMAN; CD74; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain (Ii); HG2A_MOUSE; Ia antigen-associated invariant chain (Ii | Ii chain); MHC class II-associated invariant chain;

Rabbit

A synthesized peptide derived from human CD74: 15-74

IgG

Liquid

affinity purified by Protein A

Recombinant

E9C4

35 kDa

1mg/ml

PBS, Glycerol, BSA.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD74表达于所有B细胞和某些T细胞亚类（MHC II阳性），具有几种异构体形式（33，35和41kDa），是HLA-DR的恒定链。该抗体主要用于标记生发中心及外套B细胞（80%）和R-S细胞（70%）以及少数T细胞（20%），常与其它B细胞标记如CD20或CD45RA联合检测，用于B细胞淋巴瘤的辅助诊断。

CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of, or in association with, MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]