The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Human
1:200-800
IHC-F
Human
1:200-800
IF
Human
1:200-800
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
CD99
蛋白名
CD99 antigen
亚基
Homodimer. Interacts with PILRB.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Natural killer cells.
相似性
Belongs to the CD99 family.
功能
Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.