CD57 Mouse mAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bsm-60790M
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概述
产品编号
bsm-60790M
英文名称
CD57 Mouse mAb
中文名称
髓鞘相关糖蛋白（CD57）单克隆抗体
英文别名
CD57; GLCATP; GLCUATP; HNK1; LEU7; NK-1; NK1; B3GA1_HUMAN; B3GAT1; Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P (GlcAT-P); UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (GlcUAT-P); 2.4.1.135; CD57 antigen; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; glucuronosyltransferase P
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human CD57
亚型
IgG1, k
性状
Lyophilized or Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
G14H3
理论分子量
38 kDa
浓度
1mg/ml
储存液
PBS, Glycerol, BSA.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
CD57是一种分子量为110KD的糖蛋白,它是自然杀伤细胞(NK)和杀伤细胞的特异性表面抗原。CD57表达于15-20%的外周血单核细胞，60%的NK活化细胞以及T细胞亚群。该抗体可以标记NK细胞，也可识别非淋巴组织的一些细胞。可用于NK细胞介导的细胞毒、NK细胞及T细胞亚群的功能等方面的研究，也可标记神经内分泌细胞及其肿瘤。
背景资料
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
B3GAT1
蛋白名
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
亚基
Homodimer (Potential).
亚细胞定位
Golgi apparatus membrane; Single-pass type II membrane protein.
组织特异性
Mainly expressed in the brain.
相似性
Belongs to the glycosyltransferase 43 family.
功能
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
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