G-CSF/CSF3 Rabbit pAb (一抗) | Bioss

bs-1023R

农牧业/家禽抗体

G-CSF/CSF3 Rabbit pAb

粒细胞-巨噬细胞集落刺激因子3抗体

C17orf33; CSF3OS; GCSF; CSF3_HUMAN; CSF3; G-CSF; Pluripoietin;

Rabbit

KLH conjugated synthetic peptide derived from human CSF3: 155-198/207

IgG

Liquid

affinity purified by Protein A

Polyclonal

19 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones） 集落刺激因子是一组功能很强的骨髓造血细胞增殖因子，GCSF（粒细胞克隆刺激因子）为其中一种，具有刺激粒系母细胞的增殖和分化，并可增强成熟粒细胞功能的作用。粒细胞集落刺激因子在抗感染的非特异性细胞免疫过程中起重要作用。

Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins that regulate haematopoietic cell proliferation and differentiation. G-CSF was isolated initially as a factor supporting the growth of colonies of granulocytes in soft agar cultures. Cells of the monocyte/macrophage lineage are among the most prominent sources of G-CSF, but this factor can also be produced by normal cells of mesodermal origin, including vascular endothelial cells, fibroblasts, and mesothelial cells. Production of G-CSF can be induced in vitro in these cells by a wide variety of stimulatory agents, including LPS, TNF, IL-1, IL-3, I L-4, and IFN-Gamma. G-CSF is likely to play a role in the basal regulation of neutrophil production, and also functions as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Furthermore, G-CSF exhibits other biological activities besides the proliferative effects, since G-CSF appears to modulate the distribution of neutrophils and progenitor cells within the body.