甲胎蛋白重组兔单克隆抗体
Rrmab®兔单抗
货号：bsm-60789R
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概述
产品编号
bsm-60789R
产品类型
重组兔单抗
英文名称
AFP Recombinant Rabbit mAb
中文名称
甲胎蛋白重组兔单克隆抗体
英文别名
AFPD; FETA; HPAFP; FETA_HUMAN; AFP; Alpha-1-fetoprotein; Alpha-fetoglobulin;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human alpha Fetoprotein: 1-609/609
亚型
IgG
性状
Lyophilized or Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
A5H7
理论分子量
65 kDa
浓度
1mg/ml
储存液
PBS, Glycerol, BSA.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
应用推荐（Capture-Detection）: V2007-V2006
背景资料
Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-5000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
AFP
蛋白名
alpha-fetoprotein
亚基
Dimeric and trimeric forms have been found in addition to the monomeric form.
亚细胞定位
Secreted.
组织特异性
Plasma. Synthesized by the fetal liver and yolk sac.
翻译后修饰
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Sulfated.
Sulfated.
相似性
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.
Contains 3 albumin domains.
功能
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
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具体参考文献:bsm-60789R 被引用于1文献中
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