胚胎干细胞关键蛋白重组兔单克隆抗体

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
胚胎干细胞关键蛋白重组兔单克隆抗体
货号:bsm-60788R
产品详情
相关标记
相关产品
相关文献
常见问题

概述

产品编号
bsm-60788R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
SOX2 Recombinant Rabbit mAb
中文名称
胚胎干细胞关键蛋白重组兔单克隆抗体
英文别名
ANOP3; MCOPS3; Sox-2; lcc; ysb; SOX2_HUMAN; SOX2; SOX2_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SOX2
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
D1H6
理论分子量
34 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Embryonic Stem Cell Marker (胚胎干细胞标志物)

转录因子:胚胎干细胞相关蛋白Sox2是sox基因家族的一个成员,Sox2与Oct4、Nanog一样是胚胎干细胞重要的转录因子,是维持干细胞特性中起到重要的作用因子;由于它在早期胚胎发生、神经分化和晶状体发育等多种重要的发育事件中都起着关键的作用,从而引起了越来越广泛的关注。
背景资料
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008].
胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体胚胎干细胞关键蛋白重组兔单克隆抗体

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:1000-5000
IHC-PHuman, Mouse, Rat1:200-800
IHC-FHuman, Mouse, Rat1:200-800
IFHuman, Mouse, Rat1:200-800
ICC/IFHumanMouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

相关产品

暂无相关产品

靶标

基因名
SOX2
蛋白名
Transcription factor SOX-2
亚基
Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.
亚细胞定位
Nucleus.
翻译后修饰
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
疾病
Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
相似性
Contains 1 HMG box DNA-binding domain.
功能
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

标记抗体

暂无标记数据

同靶标产品

暂无同靶标产品

相关文献

提示: 发表研究结果有使用 bsm-60788R 时请让我们知道,以便我们可以引用参考文章。作为回馈,资料提供者将获得我们送上的小礼品。

暂无相关文献

常见问题

暂无常见问题