FOLH1 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-60787R

重组兔单抗

FOLH1 Recombinant Rabbit mAb

前列腺特异膜抗原重组兔单克隆抗体

FGCP; FOLH; GCP2; GCPII; NAALAD1; PSM; PSMA; mGCP; FOLH1_HUMAN; FOLH1; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase (FGCP); Glutamate carboxypeptidase II (GCPII); Membrane glutamate carboxypeptidase (mGCP); N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I); Prostate-specific membrane antigen (PSM | PSMA); Pteroylpoly-gamma-glutamate carboxypeptidase; 3.4.17.21; folate hydrolase (prostate-specific membrane antigen) 1; glutamate carboxylase II; glutamate carboxypeptidase 2

Rabbit

KLH conjugated synthetic peptide derived from human FOLH1

IgG

Liquid

affinity purified by Protein A

Recombinant

B11A8

84 kDa

1mg/ml

PBS, Glycerol, BSA.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. Subunit : Homodimer.

FOLH1

Glutamate carboxypeptidase 2

Homodimer.

Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm.

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.

Belongs to the peptidase M28 family. M28B subfamily.