Integrin alpha 6 Rabbit pAb (一抗) | Bioss
货号：bs-2641R
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概述
产品编号
bs-2641R
产品类型
农牧业/家禽抗体
英文名称
Integrin alpha 6 Rabbit pAb
中文名称
整合素α6（CD49f）抗体
英文别名
CD49f; ITGA6A; ITGA6B; JEB6; VLA-6; 5033401O05Rik; ITA6_HUMAN; ITGA6; CD49 antigen-like family member F; ITA6_MOUSE; integrin subunit alpha 6; integrin, alpha 6; very late activation protein 6
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Integrin alpha 6: 1031-1130/1130 <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
21/124 kDa
检测分子量
124 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Developmental Biology > Embryogenesis > Embryonic stem cells > Intracellular
Signal Transduction > Cytoskeleton / ECM > Basal Lamina
Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Alpha
Stem Cells > Embryonic Stem Cells > Surface Molecules
Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Cow, Chicken | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Cow, Chicken)
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靶标
基因名
ITGA6
蛋白名
Integrin alpha-6
亚基
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.
亚细胞定位
Cell membrane; Single-pass type I membrane protein.
组织特异性
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
翻译后修饰
Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
疾病
Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 7 FG-GAP repeats.
功能
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
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