BCL10 Rabbit pAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号：bs-2733R
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常见问题
概述
产品编号
bs-2733R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
BCL10 Rabbit pAb
中文名称
BCL10抗体
英文别名
CARMEN; CIPER; CLAP; IMD37; c-E10; mE10; BCL10_HUMAN; BCL10; B-cell CLL/lymphoma 10 (Bcl-10); CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein (hCLAP); CED-3/ICH-1 prodomain homologous E10-like regulator (CIPER); Cellular homolog of vCARMEN (cCARMEN); Cellular-E10 (c-E10); Mammalian CARD-containing adapter molecule E10 (mE10);
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Bcl-10: 81-180/233
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
26 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family
Cancer > Signal transduction > Nuclear signaling > NFkB pathway
Cell Biology > Apoptosis > Intracellular > Bcl2 Family
Cell Biology > Apoptosis > Intracellular > Caspases etc > CARD Family
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human, Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1μg/Test | |
| ICC/IF | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:50-200 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse)
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暂无相关产品
靶标
基因名
BCL10
蛋白名
B-cell lymphoma/leukemia 10
亚基
Contains 1 CARD domain.
亚细胞定位
Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
组织特异性
Ubiquitous.
翻译后修饰
Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
疾病
Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. <>brNote=Defects in BCL10 are involved in various types of cancer.
Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis.
Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis.
相似性
Contains 1 CARD domain.
功能
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
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